After graduating from the University of Chemical Technology in Prague, he worked at F. Hoffmann-La Roche,Basel, where he was involved in preparation of novel drug candidates in the medicinal chemistry research department.
From F.Hoffmann-La Roche he moved to the Swiss Federal Institute of Technology in Zurich, where he dealt with the development and application of Togni reagents during his doctoral studies. Together with Prof. Dr. Antonio Togni and Dr. Petr Beier from IOCB, he discovered a family of second generation Togni reagents - hypervalent iodine-fluoroalkyl compounds with a wide range of applications not only in the field of small molecules in medicinal chemistry and agrochemistry but also in straightforward preparation of bioconjugates of biologically relevant biomolecules, especially in the direction of antibody drug conjugates for immunooncology