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Urea crosslinker – C4-arm, NHS ester (DSBU, BuUrBU)

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  • IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) 4,4'-(carbonylbis(azanediyl))dibutyrate
  • Synonyms: Urea-crosslinker C4-succinimide, C4-urea-NHS-crosslinker, DSBU, BuUrBu
  • CAS: 1240387-33-0
  • Smiles: O=C(ON1C(CCC1=O)=O)CCCNC(NCCCC(ON2C(CCC2=O)=O)=O)=O
  • Chemical formula: C17H22N4O9
  • Molecular weight: 426.38
  • Purity: 95%+

Ureido-4,4´-dibutyric acid bis(hydroxysuccinimide) ester, also known as DSBU or BuUrBU, is the longest length version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows to perform unambiguous distinguishing of crosslinks in tandem CID-MS experiments.

The urea-based MS-cleavable crosslinkers are based on the concept pioneered by Prof. Dr. Andrea Sinz of the Halle University.