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Urea crosslinker – C3-arm, NHS ester (DSPU)

Cat. # Quantity Price Lead time Buy this product
PCL007_0050 0.05 g Enquire in stock
PCL007_0100 0.1 g Enquire in stock
  • IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) 3,3'-(carbonylbis(azanediyl))dipropionate
  • Synonyms: C3-Urea-NHS-crosslinker, Urea-crosslinker C3-succinimide, DSPU
  • CAS: 2185840-20-2
  • Smiles: O=C(ON1C(CCC1=O)=O)CCNC(NCCC(ON2C(CCC2=O)=O)=O)=O
  • Chemical formula: C15H18N4O9
  • Molecular weight: 398.32
  • Purity: 95%+

Ureido-3,3´-dipropionic acid bis(hydroxysuccinimide) ester is the medium length version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows to perform unambiguous distinguishing of crosslinks in tandem CID-MS experiments.

The urea-based MS-cleavable crosslinkers are based on the concept pioneered by Prof. Dr. Andrea Sinz of the Halle University.


Download the MSDS.