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Urea crosslinker – C2-arm, NHS ester

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PCL006_0100 0,1 g in stock login to see the price
PCL006_0500 0,5 g in stock login to see the price
PCL006_1 1 g in stock login to see the price
  • IUPAC Name: bis(2,5-dioxopyrrolidin-1-yl) 2,2'-(carbonylbis(azanediyl))diacetate
  • Synonyms: C2-Urea-NHS-crosslinker; Urea-crosslinker C2-succinimide
  • CAS: 211029-82-2
  • Smiles: O=C(ON1C(CCC1=O)=O)CNC(NCC(ON2C(CCC2=O)=O)=O)=O
  • Chemical formula: C13H14N4O9
  • Molecular weight: 370,27
  • Purity: 95%+

Ureido-2,2´-diacetic acid bis(hydroxysuccinimide) ester is the shortest version of MS-cleavable urea-based lysine-lysine reactive homobifunctional cross-linkers. At neutral or slightly basic pH, it irreversibly crosslinks the neighbouring lysine groups. The presence of the symmetrical urea moiety which is prone to collision-induced dissociation allows to perform unambiguous distinguishing of crosslinks in tandem CID-MS experiments.

The urea-based MS-cleavable crosslinkers are based on the concept pioneered by Prof. Dr. Andrea Sinz of the Halle University.