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Trifluoromethyl azide 0.5 M solution in THF

Cat. # Quantity Price Lead time Buy this product
FAZ001_5 5 ml 555,00 € in stock
FAZ001_10 10 ml 800,00 € in stock
FAZ001_25 25 ml 1.100,00 € in stock
  • IUPAC Name: Trifluoromethyl azide
  • Synonyms: Perfluoromethyl azide, Azidotrifluoromethane, Trifluoromethylazide, Azido-trifluoro-methane, Azidotrifluormethan, Trifluormethylazid
  • CAS: 3802-95-7
  • Smiles: FC(F)(N=[N+]=[N-])F
  • Chemical formula: CF3N3
  • Molecular weight: 111.026

Recently, a new, elegant and scalable synthesis of trifluoromethylazide (CF3N3) solution in THF has been developed in Dr. Beier group at IOCB Prague in collaboration with CF Plus Chemicals (EP2982672A1).These otherwise difficult-to-access perfluoroalkylazides are highly reactive in copper catalyzed alkyne-azide cycloaddition reaction affording stable N-CF triazoles in a highly regioselective manner.


The efficiency of formation of these virtually unexplored perfluoroalkyltriazoles make them attractive for drug and pesticide discovery programmes. This chemistry was highlighted in Chemical and Engineering News in December 2016. Later, our collaborators demonstrated that the triazoles  prepared by copper catalyzed azide-alkyne cycloaddition can be transformed into a plethora of hitherto  unreported five-membered N-(per)fluoroalkyl heterocycles.2


Densely functionalized 4,5-disubstituted N-perfluoroalkyltriazoles could be also accessed by enamine-mediate azide-ketone [3+2] cycloaddition using easily enolisable ketones in the presence of catalytic amounts of pyrrolidine.3


1) Angew. Chem. Int. Ed., 2017, 56, 346.

2) Chem. Commun., 2018,  54, 3258-3261.

3) Chemistry Select, 2018, 3, 7045-7048.

Download the MSDS