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Trifluoroethyl azide 0.5 M solution in DME

Cat. # Quantity Price Lead time Buy this product
FAZ004_5 5 ml 210,00 € in stock
FAZ004_10 10 ml 325,00 € in stock
FAZ004_25 25 ml 660,00 € in stock
  • IUPAC Name: 2-Azido-1,1,1-trifluoroethane
  • Synonyms: CF3CH2N3, 1-Azido-2,2,2-trifluoroethane
  • CAS: 846057-92-9
  • Smiles: FC(F)(F)CN=[N+]=[N-]
  • Chemical formula: CF3CH2N3
  • Molecular weight: 125.05

2,2,2-Trifluoroethylazide represents a complementary fluorinated azide that can be used to access N-trifluroethylated triazoles in a regioselective fashion using the established copper catalyzed azide-alkyne cycloaddition.

Trifluoroethyl azide also undergoes Ru-catalyzed 1,5-cycloaddition, providing access to complementary triazole isomers.1

When combined with triphenylphoshine, it immediately forms the corresponding stable iminophosphorane which can be reacted with aldehydes, furnishing hard-to-synthesise N-trifluoroethyl aldimines2, that can undergo further synthetic transformations, for example reduction to N-trifluoroethylated amines that have significantly lower pKa values compared to non-fluorinated counterparts.


1) WO2021/204800, 2021, A1

2) J. Fluor. Chem., 2006, 127 (9), 1152-1157. 

Download the MSDS