|Cat. #||Quantity||Price||Lead time||Buy this product|
|FAZ004_5||5 ml||210,00 €||in stock|
|FAZ004_10||10 ml||325,00 €||in stock|
|FAZ004_25||25 ml||660,00 €||in stock|
2,2,2-Trifluoroethylazide represents a complementary fluorinated azide that can be used to access N-trifluroethylated triazoles in a regioselective fashion using the established copper catalyzed azide-alkyne cycloaddition.
Trifluoroethyl azide also undergoes Ru-catalyzed 1,5-cycloaddition, providing access to complementary triazole isomers.1
When combined with triphenylphoshine, it immediately forms the corresponding stable iminophosphorane which can be reacted with aldehydes, furnishing hard-to-synthesise N-trifluoroethyl aldimines2, that can undergo further synthetic transformations, for example reduction to N-trifluoroethylated amines that have significantly lower pKa values compared to non-fluorinated counterparts.
1) WO2021/204800, 2021, A1
2) J. Fluor. Chem., 2006, 127 (9), 1152-1157.