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Tetrafluoropropyl azide 0.5 M solution in DME

Cat. # Quantity Price Lead time Buy this product
FAZ007_5 5 ml 250,00 € in stock
FAZ007_10 10 ml 390,00 € in stock
FAZ007_25 25 ml 790,00 € in stock
  • IUPAC Name: 2,2,3,3-tetrafluoropropanyl azide, 2,2,3,3-tetrafluoropropylazide
  • Synonyms: Tetrafluoropropyl azide
  • CAS: 846057-93-0
  • Smiles: FC(C(F)(CN=[N+]=[N-])F)F
  • Chemical formula: C3H3F4N3
  • Molecular weight: 157.071

2,2,3,3-Tetrafluoropropyl represents a complementary fluorinated azide that can be used to access N-tetrafluoropropylated triazoles in a regioselective fashion using the established copper catalyzed azide-alkyne cycloaddition.

When combined with triphenylphoshine1, it immediately forms the corresponding stable iminophosphorane which can be reacted with aldehydes, furnishing hard-to-synthesize N-tetrafluoropropylated aldimines, that can undergo further synthetic transformations, for example reduction to N-tetrafluoro amines that have significantly lower pKa values compared to non-fluorinated counterparts.

The highly polarized RCF2CF2H group of tetrafluoropropylated compounds can act as a mild hydrogen bond donor.


1) J. Fluor. Chem., 2006, 127 (9), 1152-1157. 

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