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Di-(N-succinimidyl) succinate

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PCL010_1 1 g in stock login to see the price
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  • IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) succinate
  • Synonyms: Disuccinimidyl succinate, Disuccinimidyl butanedioate, Di(N-succinimidyl) succinate
  • CAS: 30364-60-4
  • Smiles: O=C(ON1C(CCC1=O)=O)CCC(ON2C(CCC2=O)=O)=O
  • Chemical formula: C12H12N2O8
  • Molecular weight: 312.23
  • Purity: 98%+

Di-(N-succinimidyl) succininate is an amine-reactive homobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups and N-termini. While generally less often used than DSG, DSS and DSSeb, protein structure analysis based on chemical crosslinking with disuccinimidyl succinate can generate additional structural information.