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Di-(N-succinimidyl) sebacate

Cat. # Quantity Price Lead time Buy this product
PCL003_1 1 g 50,00 € in stock
PCL003_5 5 g 190,00 € in stock
PCL003_10 10 g 300,00 € in stock
PCL003_50 50 g 1.350,00 € in stock
  • IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) decanedioate
  • Synonyms: DSSeb, Disuccinimidyl sebacate, Disuccinimidyl decanedioate
  • CAS: 23024-29-5
  • Smiles: O=C(ON1C(CCC1=O)=O)CCCCCCCCC(ON2C(CCC2=O)=O)=O
  • Chemical formula: C18H24N2O8
  • Molecular weight: 396.39
  • Purity: 98%+

Di-(N-succinimidyl) sebacate is an amine-reactive homobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups and N-termini. It represents the longest of the 3 most used neutral N-crosslinkers.

DSSeb crosslinker (Disuccinimidyl sebacate; Sebacic acid bis[N-hydroxysuccinimide ester]) is a homobifunctional crosslinking reagent which is cell membrane permeable. DSSeb crosslinking takes place via amine-reactive NHS esters at both ends of a 10-atom (14.1 Angstrom) spacer arm. DSSeb must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.