Di-(N-succinimidyl) glutarate (DSG)
| Cat. # | Quantity | Price | Lead time | Buy this product |
|---|---|---|---|---|
| PCL001_1 | 1 g | 110,00 € | in stock | |
| PCL001_5 | 5 g | 420,00 € | in stock | |
| PCL001_10 | 10 g | 670,00 € | in stock | |
| PCL001_50 | 50 g | 2.300,00 € | in stock |
- IUPAC Name: Bis(2,5-dioxopyrrolidin-1-yl) glutarate
- Synonyms: DSG, Disuccinimidyl glutarate, Bis-succinimidyl glutarate, Disuccinimidyl pentanedioate
- CAS: 79642-50-5
- Smiles: O=C(CCCC(ON1C(CCC1=O)=O)=O)ON2C(CCC2=O)=O
- Chemical formula: C13H14N2O8
- Molecular weight: 326.26
- Purity: 98%+
Di-(N-succinimidyl) glutarate is an amine-reactive homobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups and N-termini. It represents the shortest of the 3 most used neutral N-crosslinkers (DSG, DSS, DSSeb). DSG crosslinking takes place through amine-reactive NHS esters at both ends of a 5-atom (7.7 angstrom) spacer arm. DSG must be dissolved in an organic solvent, such as DMSO or DMF, then added to an aqueous crosslinking reaction.