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Di-(N-succinimidyl)-3,3´-dithiodipropionate

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PCL011_1 1 g in stock login to see the price
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  • IUPAC Name: 2,5-Dioxocyclopentyl 3-((3-((2,5-dioxopyrrolidin-1-yl)oxy)-3-oxopropyl)disulfaneyl)propanoate
  • Synonyms: 3,3′-Dithiodipropionic acid di(N-hydroxysuccinimide ester), Di(N-succinimidyl) 3,3′-dithiodipropionate, Dithio-bis-succinimidyl propionate, Dithiobis(succinimidyl propionate), Lomant’s reagent, DSP cross-linker, DTSP crosslinker
  • CAS: 57757-57-0
  • Smiles: O=C(ON1C(CCC1=O)=O)CCSSCCC(OC2C(CCC2=O)=O)=O
  • Chemical formula: C14H16N2O8S2
  • Molecular weight: 404.42
  • Purity: 98%+

Di-(N-succinimidyl) 3,3-dithiodipropionate is an amine-reactive homobifunctional cross-linker with a cleavable disulfide moiety. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups and N-termini. The resulting crosslinks can be effectively cleaved under reductive conditions, for example by treatment with DTT or TCEP.