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Cat. # Quantity Price Lead time Buy this product
FAZ009_0050 0.05 g 415,00 € in stock
FAZ009_0100 0.1 g 600,00 € in stock
FAZ009_0250 0.25 g 1.000,00 € in stock
  • IUPAC Name: 2-Azido-2,2-difluoroacetamide
  • Synonyms: Azidodifluoroacetamide
  • CAS: 2102183-90-2
  • Smiles: NC(C(F)(N=[N+]=[N-])F)=O
  • Chemical formula: C2H2F2N4O
  • Molecular weight: 136.06
  • Purity: 95%+

Azidodifluoroacetamide introduces a fluorinated amide to drug candidates by click chemistry.

Owing to the electron withdrawing effect of fluorine substituents, azidodifluoroacetamide-derived triazoles are expected to have significantly lower pKa values than their non-fluorinated counterparts, comparable to trifluoroacetamide.

Furthermore, when attached to an alkynylated biolomolecule (protein, peptide, nucleic acid, glycan, etc.) or advanced material, it can act as a 19F NMR sensor of its surroundings.

Despite the relatively low 19F NMR integration intensity, it can be beneficial in cases where organic cosolvents should be avoided or aqueous solubility of the resulting conjugate must not be compromised or should be improved. .

Download the MSDS