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Cat. # Quantity Price Lead time Buy this product
FAZ014_0050 0.05 g 950,00 € in stock
FAZ014_0100 0.1 g 1.650,00 € in stock
FAZ014_0250 0.25 g 3.500,00 € in stock
  • IUPAC Name: 5-azido-1,1,1-trifluoro-2-(trifluoromethyl)pentan-2-ol
  • Synonyms:
  • CAS: N/A
  • Smiles: OC(C(F)(F)F)(C(F)(F)F)CCCN=[N+]=[N-]
  • Chemical formula: C6H7F6N3O
  • Molecular weight: 251.13
  • Purity: 95%+

5-Azido-1,1,1-trifluoro-2-(trifluoromethyl)pentan-2-ol is a convenient source of a mildly acidic bis(trifluoromethyl)carbinol moiety that can be reliably attached by click chemistry.

Bis-trifluoromethyl carbinol group was an essential part of malonyl-CoA decarboxylase inhibitors1 and LXR inhibitors by providing essential H-bonding contacts to histidine residues present in the binding domain of the protein.2,3

When attached to an alkynylated biomolecule (protein, peptide, nucleic acid, glycan, etc.) or advanced material, the 6 magnetically equivalent fluorines can act as 19F NMR sensor of its surroundings, for example by H-bonding to neighbouring amino acid side chains.


1) Bioorg. Med. Chem. Lett., 2006, 16 (13), 3484-3488.

2) J. Biol. Chem., 2003, 278, 27138.

3) J. EMBO, 2003, 22, 462.

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