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SMCC crosslinker

Cat. # Quantity Price Lead time Buy this product
PCL025_0050 0,05 g 18,00 € in stock
PCL025_0100 0,1 g 25,00 € in stock
PCL025_0250 0,25 g 40,00 € in stock
PCL025_1 1 g 90,00 € in stock
  • IUPAC Name: 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester
  • Synonyms: 4-(N-maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester, 4-(N-maleimidomethyl)cyclohexane-1-carboxylic acid succinimidyl ester, N-succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, succinimidyl 4-(N-maleimidomethyl)cyclohexane-1-carboxylate, succinimidyl-4-(N-maleimidomethyl)cyclohexane-1-carboxylate, Maleimidylmethyl-4-trans-cyclohexylcarboxysuccinate, SMCC
  • CAS: 71875-81-5
  • Smiles: O=C(CC1)N(OC([C@@H]2CC[C@@H](CN3C(C=CC3=O)=O)CC2)=O)C1=O
  • Chemical formula: C16H18N2O6
  • Molecular weight: 334.329
  • Purity: 97%+

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is a heterobifunctional cross-linking reagent containing amine and sulfhydryl reactivity. It is typically coupled initially to molecules containing primary amine by amide bond buffered at pH 7.5 (6.5-8.5). The second coupling is specific for molecules containing free sulfhydryl by thioether linkage buffered at pH 6.8 (6.5-7.0). SMCC contains nine atom linker. An extended aliphatic spacer stabilizes the maleimide prior to coupling compared to aromatic spacers.

4-(N-Maleimidomethyl)cyclohexanecarboxylic acid N-hydroxysuccinimide ester (SMCC) is useful for the preparation of enzyme immunoconjugates and hapten carrier molecule conjugates.