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4-Azidobenzoic acid NHS ester

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PCL013_0500 0,5 g in stock login to see the price
PCL013_1 1 g in stock login to see the price
  • IUPAC Name: 2,5-dioxopyrrolidin-1-yl 4-azidobenzoate
  • Synonyms: 4-Azidobenzoic acid NHS ester; NHS ABA; NHS azidobenzoate; 2,5-dioxopyrrolidin-1-yl 4-azidobenzoate
  • CAS: 53053-08-0
  • Smiles: O=C(ON1C(CCC1=O)=O)C2=CC=C(N=[N+]=[N-])C=C2
  • Chemical formula: C11H8N4O5
  • Molecular weight: 276,21
  • Purity: 95%+

4-Azidobenzoic acid NHS ester is an amine-reactive heterobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups, N-termini and amines and installs the arylazido group that can be subsequently transformed to a reactive nitrene by irradiation with short wavelenghts (250 nm). The in-situ generated nitrene reactive intermediate is highly reactive and immediately gets captured by surrounding nucleophiles.