4-Azidobenzoic acid NHS ester
| Cat. # | Quantity | Lead time | Buy this product |
|---|---|---|---|
| PCL013_0500 | 0.5 g | in stock | login to see the price |
| PCL013_1 | 1 g | in stock | login to see the price |
| PCL013_5 | 5 g | in stock | login to see the price |
| PCL013_10 | 10 g | in stock | login to see the price |
- IUPAC Name: 2,5-Dioxopyrrolidin-1-yl 4-azidobenzoate
- Synonyms: NHS ABA, NHS Azidobenzoate
- CAS: 53053-08-0
- Smiles: O=C(ON1C(CCC1=O)=O)C2=CC=C(N=[N+]=[N-])C=C2
- Chemical formula: C11H8N4O5
- Molecular weight: 276.21
- Purity: 95%+
4-Azidobenzoic acid NHS ester is an amine-reactive heterobifunctional cross-linker. At neutral or slightly basic pH (7-9), it rapidly attacks solvent accessible lysine-NH2 groups, N-termini and amines and installs the arylazido group that can be subsequently transformed to a reactive nitrene by irradiation with short wavelenghts (250 nm). The in-situ generated nitrene reactive intermediate is highly reactive and immediately gets captured by surrounding nucleophiles.