|Cat. #||Quantity||Price||Lead time||Buy this product|
|FAZ020_0050||0.05 g||450,00 €||in stock|
|FAZ020_0100||0.1 g||750,00 €||in stock|
|FAZ020_0250||0.25 g||1.600,00 €||in stock|
4-Azidophenyl-bis(trifluoromethyl)carbinol is a convenient source of a mildly acidic bis(trifluoromethyl)carbinol moiety that can be reliably attached by click chemistry.
Bis-trifluoromethyl carbinol group was an essential part of malonyl-CoA decarboxylase inhibitors1 and LXR inhibitors by providing essential H-bonding contacts to histidine residues present in the binding domain of the protein.2,3
When attached to an alkynylated biomolecule (protein, peptide, nucleic acid, glycan, etc.) or advanced material, the 6 magnetically equivalent fluorines can act as 19F NMR sensor of its surroundings, for example by H-bonding to neighbouring amino acid side chains.
1) Bioorg. Med. Chem. Lett., 2006, 16 (13), 3484-3488.
2) J. Biol. Chem., 2003, 278, 27138.
3) J. EMBO, 2003, 22, 462.